Medicinal Chemistry Services / Organic Chemistry Services
Pharmacology Services
Averin Biotech Pre-clinical Services are designed to help you through the drug candidate selection process and to bridge the gap between the laboratory and clinical phase of research for pharmaceutical and biotechnology products..
Just as importantly, it has been successfully tried and tested by many clients who needed support during preclinical and clinical studies for regulatory submissions of investigative and new drugs. Working to the same high standards that underpin all of our services, our experts will help you evaluate the potential of a drug candidate to move into the more costly clinical phases of research. Through our preclinical laboratory services, we will analyze the initial pharmacokinetics and toxicokinetics of your investigational product.
Pharmacology Services
In vivo Activity
DLA/EAC induced ascitic tumor model in mice
DLA induced solid tumor model in mice
In Vitro Activity
Cytotoxicity assay by MTT/SRB/Trypan blue
Clonogenic assay
Apoptosis – Nuclear staining with DAPI
Alkylating activity assay
TUNEL assay
Endonuclease assay
DNA fragmentation analysis / DNA ladder assay
Cancer specific gene expression analysis
P53, BCl2, Capsase 3, VEGF, cyclin D1, cyclin B1, STAT3 etc.
Anti Diabetes Activity ( In vivo Activity )
Alloxan induced diabetic rat model
Streptozotocin induced diabetic rat model
Glucose uptake studies in skeletal muscle cell lines (Non-radio labeled assay).
Glucose uptake in isolated rat hemi diaphragm
Gene expression studies (PPARγ, GLUT-4 etc)
Alpha-Amylase inhibitory activity
Alpha-galactosidase inhibitory activity
Alpha-glucosidase activity
Hepatoprotective Activity / In vivo Activity
Hepatoprotective study against selected toxicant in rats In Vitro Activity
Hepatoprotective study against selected toxicant.
Hepatoprotective study in isolated primary rat hepatocytes.
Gene expression studies
Anti infective Activity In vivo Activity
Different wound healing models in mice/rats
Anti microbial activity by Zone of inhibition.
Anti microbial activity by MIC determination
Antibiotic sensitivity testing
TLC bioautography
In vitro anti viral studies
Other in vivo services
Hypercholesterolemia
Arthritis
Osteoporosis
Benign prostatic Hyperplasia
Spermatogenesis
Allergy
Antitussive
Psoriasis
Other Services
Antimicrobial
Anti viral
Cytotoxicity
Cell proliferation
Cancer
Diabetes
Hepatoprotection
Obesity
Immunomodulatory
Inflammation
Skin whitening
Skin irritation (Dermal toxicity)
Psoriasis
Wound healing
Genotoxicity
Drug permeability
Gene expression analysis
Enzyme and Immunoassays (ELISA)
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